From the single MIS class I took at UTD, it seems to be a general business degree with a focus exploiting computer systems to reduce tedium. we focused heavily on the supply chains and system inputs and outputs, talked about things such as processes from an extremely high-level overview, "learned what a database was for", and had a bunch of different documents (requisition request, product order form, etc) we had to memorize.
The emphasis was on automating real world processes using pre-existing systems
I assume (and the key word there is ass-u-me), that most people that get an MIS degree will go into management or finance, and work closely with managing data on a computer, and won't end up doing much system analysis / design / development.
I've since changed my major to Computer Science, and I'm getting a lot more training in systems design and development, rather than systems exploitation.