If you're asking about functional testing (with database, fixtures etc.), then I don't see any specific problems with neither framework-specific tools nor more abstract python
requests library. More of that, testing rest API is far more simpler than doing that with static content.
Simple example is here: http://www.redhotchilipython.com/en_posts/testing_python/functional.html (maybe I should take a time and finish that long post one day).
The main problems are rather with good quality of your factories to generate test-data, with parts of response you're going to test (you should be careful and concentrate and to run your predicates against test-subject, but not other pieces of data, otherwise you'll be trapped into "change one letter -> go fix 100 tests" hell).
If you're asking about unit-testing views, then it's no different then testing any other functions. I highly recommend my mockstar library for mocking away all side-effects declaratively, by the way.