Tiling isn't anything new. You can see in many places these days. From the Android Play store, to how Google+ and Facebook now show uploaded images in the feed. So I wouldn't say tiling is the main feature of the new Metro UI. I feel that it is the look and placement of those tiles and how they interact and how the UI flows that Microsoft has the patent on.
If you look at the USPTO filing, the abstract is as follows:
Aspects of a user interface that provides visual feedback in response
to user input. For example, boundary effects are presented to provide
visual cues to a user to indicate that a boundary in a movable user
interface element (e.g., the end of a scrollable list) has been
reached. As another example, parallax effects are presented in which
multiple parallel or substantially parallel layers in a multi-layer
user interface move at different rates, in response to user input. As
another example, simulated inertia motion of UI elements is used to
provide a more natural feel for touch input. Various combinations of
features are described. For example, simulated inertia motion can be
used in combination with parallax effects, boundary effects, or other
types of visual feedback.
I know, it's quite a wall of text and written in a lot of abstract jargon to make it as broad a possible, but really it comes down to the tiled interface working well on a touch screen to provide clear user feedback.
So yes, I'd say you can use a tiled layout for your site so long as you don't copy all the UI elements and visual cues from the new Metro interface.